What a ridiculous name! I have made several requests that the name of the protocol is changed, but it was created in Japan, so I have little influence. There are 5 drugs that make up the protocol which give the acronym SMILE. The drugs that Ryan is subjected to are as follows: Steroid Dexamethasone , days 2-4: A steroid used as an anti-inflammatory, increase appetite, prevents reactions. Side effects: Muscle weakness, mood swings, insomnia. Methotrexate , day 1: A cytotoxic - Anti Cancer Antimetobolite drug that prevents cell division. Side effects: Neutropenia, Alopecia, Fertility. Ifosfamide , days 2-4: A cytotoxic - Anti Cancer Alkylating Agent that changes cell DNA. Side effects: Neutropenia, Alopecia, Fertility. L-asparaginase , day 8: A cytotoxic - Anti Cancer Pancreatitis Enzyme that breaks down asparagine in the body. Since the cancer cells cannot make more asparagine, they die. Side effects: Anaphylaxis, Neurotoxicity, Liver function. Etoposide , days 2-4: A cytotoxic -
ASC and Teenage Cancer. Join our winding and bumpy trip down Lymphoma Road, stopping at Autism Central.